Post by Dunwik on Aug 1, 2023 17:11:19 GMT
JULY 5th, 1921
The drug known as penicillin, while demonstrated at the World's Fair 1920, was still something in its infancy, demonstrated only in small quantities. Little about the substance was known, aside from its remarkable efficacy at destroying bacteria in a petri dish and how incredibly well it was tolerated in human subjects. The joint Dunwikki-Divinian team that had discovered it still languished in relative obscurity, for massive clinical trials were not yet underway and synthesis in quantity was beyond medical science. It was most curious indeed that the team authored a report and sent it in every language they could conceive of, to every university and physician they could find, with a single, simple warning:
"While the potential applications of penicillin are substantial, we must be extremely conservative with the use of it, or any future alternate anti-microbial agent. The probability that bacteria would evolve resistance to such agents increases with use and exponentially with misuse. We possess great faith in penicillin and know it shall cure illnesses currently deemed incurable, but we urge all who read our warnings not to follow outlandish claims or use any tool beyond what it is designed for. We wish that penicillin or any similar future agent discovered to be made illegal to possess or administer without a medical license and that it only be administered for bacterial infections, and only in doses high enough to prevent any bacteria from gaining resistance to it. It would be an unspeakable tragedy if this tool was lost through negligence and imprudence."
Attached was a scientific paper demonstrating the possibility for bacterial populations to evolve resistance to penicillin, (by means of culturing bacteria in agar with ever-increasing quantities of penicillin in it, showing not only the evolution of resistance but also the possibility of horizontal gene transfer) that was published in a prestigious Dunwikki journal.
The drug known as penicillin, while demonstrated at the World's Fair 1920, was still something in its infancy, demonstrated only in small quantities. Little about the substance was known, aside from its remarkable efficacy at destroying bacteria in a petri dish and how incredibly well it was tolerated in human subjects. The joint Dunwikki-Divinian team that had discovered it still languished in relative obscurity, for massive clinical trials were not yet underway and synthesis in quantity was beyond medical science. It was most curious indeed that the team authored a report and sent it in every language they could conceive of, to every university and physician they could find, with a single, simple warning:
"While the potential applications of penicillin are substantial, we must be extremely conservative with the use of it, or any future alternate anti-microbial agent. The probability that bacteria would evolve resistance to such agents increases with use and exponentially with misuse. We possess great faith in penicillin and know it shall cure illnesses currently deemed incurable, but we urge all who read our warnings not to follow outlandish claims or use any tool beyond what it is designed for. We wish that penicillin or any similar future agent discovered to be made illegal to possess or administer without a medical license and that it only be administered for bacterial infections, and only in doses high enough to prevent any bacteria from gaining resistance to it. It would be an unspeakable tragedy if this tool was lost through negligence and imprudence."
Attached was a scientific paper demonstrating the possibility for bacterial populations to evolve resistance to penicillin, (by means of culturing bacteria in agar with ever-increasing quantities of penicillin in it, showing not only the evolution of resistance but also the possibility of horizontal gene transfer) that was published in a prestigious Dunwikki journal.